Dear Synthesis,
thanks for coming back. I was slightly worried that you would turn away when part of this thread turned sarcastic. Please stay. We might become best friends.
What I am trying to say and to help everyone out in the forums is be careful what you ingest...
I got that. It was evident from your tone that you a) had good intentions b) a scientific background/approach.
Also, your wrong about "You seem to have criteria that don't apply to what people are doing here"
Since you are a scientist, I will nitpick words with you because in your line of work precision is very important.
I am not wrong about "You seem..." because that is MY impression. Semantics.
Regarding the rest of the statement, I still believe my opinion holds water. The people on this forum that are producing AuNP is doing it for a practical application right NOW, with a health problem as focus. "Our" AuNP:s are NOT intended to hook up other molecules for signals, drug delivery etc (functionalizing). What you are working with/researching is something else. You need vast precision, especially when functionalizing the clusters since the outcome might be extremely different depending on size. The end GOAL for "you" and "us" is the same it seems - new vehicles and methods for curing disease.
Your timeline is 10 years. The timeline for many on this forum is NOW. The forum members and their relatives, friends and acquaintances have BIG health problems NOW, unresolved by current medical science - and in some cases the health problems were even caused by medical "science".
You be the judge - I have Alzheimer friends that are turning into vegetables - as - we - speak. Now. Right f-ing now. They have NO current help in sight. One is a member of a double blind study on omega-3 lipids. She asked the scientists if she was going to get better. They said "No". So much for minimizing placebo, maximizing nocebo and eradicating hope. Most in the medical community and alternative community is looking for a silver bullet for a certain disease. IMHO many of the currently incurable diseases are just the net result of one or several dysfunctional processes deep in the process chain - and in a homeostatic self-regulating system like the body where different processes kick in to compensate for others not working, it might take a very long time before the problem surfaces and pops out as a "disease" like Alzheimers, MS, Parkinson, arthritis etc - we all know that a fever can be caused by hundreds of different diseases/causes. Most people seem to look for ONE cause for Alzheimers etc. and ONE cure. Should my friends wait 10 years for the research to advance? They don't have 10 years. So - I give them curcumin liposomes+vitamin D3 (to stimulate potentially beta-amyloid plaqcue eating macrophages type I and II as well as ease inflammation), omega-3, coconut oil (for ketones - insulin resistance in the brain is another hypothesis), colloidal silver to clear up potential chronic low level infections, and colloidal gold for a POTENTIAL cognitive boost (according to Guy E. Abrahams reports). NONE of these "cures"/"methods" are in the "book"/approved - but there exists budding research pointing in these directions as well as anecdotal evidence and some layman research.
(comment on Guy E. Abraham - he seems mostly self-published, but his work seems honest, professional, experienced and clear - his gold studies are just a small part - I guess he is results focused, aged, not in the grants/peer-approval-circuit anymore)
With NO "approved" alternatives and the end result inevitable regarding Alzheimers- vegetable state - would you sit down and gracefully accept that destiny, or would you look for a way? Especially if that way HAS some substance? Especially if the way consists of methods that seem quite harmless/non-toxic? If your mother was suffering today - what would you do? AFAIK, maybe your research impulse is motivated by a history of disease in your family.
Extend the above moral dilemma to any disease you want. I've taken sides.
I spend alot of my time trying to understand nanoparticles to help people.
Commendable. Sometimes you have to act, too. In your position that could ruin your upcoming career unless you are very careful. I have no such career.
You can't get more dedicated than me unless your my advisor.
I like your style, I am placing the above in the rhetorical box, not in the truth box.
<snip> Cutting away text pointing to precision and exact methods, where I fully agree and understand the authors position. <snip>
You are thoroughly mistaking this forum to be aiming at producing papers, academic results, achieving an exact result (good enough is ANOTHER criteria). I am not saying that you are doing anything wrong, I am saying that you are applying you world view to something that does not fit/match your world view.
We dabble in your field because we NEED results NOW. If you would dabble in my field, I could knock you down on a thousand fine points - but I would be able to see if your dabbling was getting you results and/or was worth a shot. Different standards for different worlds.
I would LOVE to have the time, resources, money and subjects to test 18 nm, 19 nm, 20 nm, etc in vivo in different dosages using different protocols. I currently don't. I have businesses to run, projects to complete, patents to formulate, friends to help, people to heal, stuff to learn, family to love and take care of. Life is not about exploring an isolated variable across one dimension. Life is finding a path with those constraints that are given you - finding your local maximas in a multidimensional space. The ivory tower environment is one space with certain constraints, the outer world has other constraints.
Maybe your criteria isn't true to the cause to many of us working on nanoparticle for biological application ShivaDestructor... We follow rules and ethics because we have to.
"we" as in "me and my fellow researchers" I presume.
The FDA is in place to guide us on human/ animal trials and release...You can't blame a few corrupt people in the FDA (everyone is human and everyone has their price)
It seems that we actually can blame a few corrupt people in the FDA since they obviously have VAST impact. Since you seem to be a budding idealist, I will also correct you by claiming that a few, precious few people do not have a price.
without their rules, ethics and guide lines... It will be a slaughter house...
Agreed. I am not fond of people selling saw dust as fat loss agents - and that is one of the most innocuous scams I've heard of, yet it makes me quite upset.
For all you people out their that is against us. walk in our shoes or think like us for once and you will understand what we do isn't for us...
Use that same argument and apply it to yourself in this context. Do not mistake me for not having a surface to academia. You would be surprised.
We care about the population as a whole and willing to sacrifice our time to help
Pure projection from your part, but it is good to know where you come from.
but to be honest if researchers started to think like you guys their will be no progress because honestly the majority if not all don't have that sickness or disease why should we care... Keep that in mind....
Your eloquence and line of reasoning broke down in the later part of your post which is a pity. Stick around. I want to know you.
As a parting note: I just walked the dog and ran into my neighbor - she wanted more colloidal silver. She got some a few weeks ago when I rang her doorbell and found her doubled over by severe pain from a urinary tract infection. Two days on colloidal silver, infection gone - much quicker than when she normally uses antibiotics for the same disease. No disease recurring yet although the dose was small. One of her dogs have had a recurring rash in his ear, treated by veterinaries and antibiotics and antifungals again and again since he was a puppy for several years... two days of topical colloidal silver - rash gone. After my neighbor got rid of her urinary tract infection, she also noticed that a year long pain in the neck (literally) was gone! No clue what it was - but it disappeared with a low dose of colloidal silver.
That colloidal silver was home cooked, with a clear golden color, not standardized, nor researched - and it did good. It helped. Am I a bad guy? Am I irresponsible? Am I misguided? Am I uninformed? Think about quoting and research - it is a trust network, often fed by agendas. Oh, I forgot about the part where you hinted about the reports not telling the whole truth - that is self-evident, at least if you do business and file patents.
Warmly,
/J