Author Topic: Zinc Oxide and Colloidal Silver or IS  (Read 1144 times)

alexp5

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Zinc Oxide and Colloidal Silver or IS
« on: February 05, 2017, 06:38:54 PM »
Would  powder form of Zinc Oxide cost destruction of IS or Colloidal Silver when they would meet in ointment ?  Thinking to make one more ointment with just Zinc Oxide instead Herbal extract, that would be not that burning as strong herbal extract does. 
Thank you

Offline nix2p

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Re: Zinc Oxide and colloidal silver or IS
« Reply #1 on: February 05, 2017, 07:20:40 PM »
Alexp5, here an article on Zinc and possible work-arround...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386201/#sec1-4title

Quote
The results of this study showed that AgNPs significantly increased the activities of GPX and CAT and the other NPs (ZnONPs and AuNPs) significantly decreased CAT and GPX activities in 2 weeks. The cytotoxicity of AuNPs has been studied in human cells and the results have shown that AuNPs are nontoxic up to 250 mM, while ionic gold exhibits obvious cytotoxicity at 25 mM.[18] Most studies have shown the toxicity of AuNPs of diameter 4-18 nm.[19] Intraperitoneal injection of AuNPs was investigated by Lasagna-Reeves et al. and the result showed a low level of toxicity at the dose range of 320-3200 mg/kg/day.[20] Zhang et al. used AuNPs at the dose of 100 mg/kg which resulted in harm to the tissues and enzymes and they had toxic effect.[21] Hussain et al. observed that AgNPs have toxic effect on the mitochondria of liver and result in the production of ROS and they decrease glutathione in the liver;[22] but in this study, GPX enzyme activity was found to be increased. Hasen and Negley showed that AuNPs result in the production of free radical of peroxidation of unsaturated fatty acid in phospholipid membrane and result in the creation of apoptosis.[23] Halo and Chen reported that the ZnONPs caused significant decrease of GSH and CAT enzymatic activities[24] and a similar result was obtained in this study. The results of the study of Zhaox et al. showed that generation of ROS was significantly increased at a concentration of 50 and 100 mg/L of ZnONPs.[25] At sizes larger than 5 nm, the general assumption is that gold is chemically inert like the bulk; however, reactivity of AuNPs of diameter less than 3 nm is most likely different from that of larger AuNPs.[26] The organ distribution of large AuNPs is size dependent, while small AuNPs of 5-15 nm diameters have wider organ distribution than that of large AuNPs of diameter 50-100 nm.[27]

CONCLUSION

The findings of this preliminary study suggest that AuNPs and ZnONPs of 10 nm diameter significantly decrease CAT and GPX enzyme activities, while AgNPs significantly increase the antioxidant enzyme activities and decrease the level of free radicals.

Modified added:

Antimicrobial particles of silver and barium sulfate or zinc oxide
https://www.google.com/patents/US5595750

« Last Edit: February 05, 2017, 07:47:16 PM by nix2p »
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